1055899-89-2Relevant academic research and scientific papers
Selective angiotensin II AT2 receptor agonists devoid of the imidazole ring system
Murugaiah,Wallinder, Chalotta,Mahalingam,Wu, Xiongyu,Wan, Yiqian,Plouffe, Bianca,Botros, Milad,Karlen, Anders,Hallberg, Mathias,Gallo-Payet, Nicole,Alterman, Mathias
, p. 7166 - 7183 (2008/09/17)
A versatile parallel synthetic method to obtain three series of non-cyclic analogues of the first drug-like selective angiotensin II AT2 receptor agonist (1) has been developed. In analogy with the transformation of losartan to valsartan it was
NEW BICYCLIC ANGIOTENSIN II AGONISTS
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Page 51-52, (2010/02/07)
There is provided compounds of formula (I), wherein R1a, R1b, n, Y1, Y2, Y3, Y4, Z1, Z2, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.
