1055963-08-0

Basic information

• Product Name: 2-(5-([(2R)-2-amino-3-(4-fluorophenyl)propyl]oxy)pyridin-3-yl)-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine
• CAS NO: 1055963-08-0
• Molecular Weight: 499.545
• Mol File: 1055963-08-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(5-([(2R)-2-amino-3-(4-fluorophenyl)propyl]oxy)pyridin-3-yl)-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-([(2R)-2-amino-3-(4-fluorophenyl)propyl]oxy)pyridin-3-yl)-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine(1055963-08-0)
• EPA Substance Registry System: 2-(5-([(2R)-2-amino-3-(4-fluorophenyl)propyl]oxy)pyridin-3-yl)-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine(1055963-08-0)

Safety Data

• Hazardous Substances Data: 1055963-08-0(Hazardous Substances Data)

Relevant articles and documents

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

A series of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamine-based inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) has been identified. Several examples appear to be potent and relatively selective inhibitors of PDK-1 over the related AGC kinases PKA, PKB/AKT, and p70S6K. The introduction of a stereochemical center beside the amino substituent on the aminoalkoxy-side chain had little effect upon the inhibitory activity against these enzymes, and X-ray crystallographic analyses of a representative pair of enantiomeric inhibitors bound to the active site of PDK-1 revealed comparable binding modes for each enantiomer.