1055992-74-9Relevant academic research and scientific papers
Preparation and biological evaluation of key fragments and open analogs of scleritodermin A
Sellanes, Diver,Campot, Francisco,Nú?ez, Ivana,Lin, Gerardo,Espósito, Pablo,Dematteis, Sylvia,Salda?a, Jenny,Domílnguez, Laura,Manta, Eduardo,Serra, Gloria
scheme or table, p. 5384 - 5395 (2010/08/19)
The synthesis of key fragments of scleritodermin A, their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed.Highlights of the synthetic route include formation of the a-ketoamide linkage and use of stereocontrolled reactions.Open analogs of this natural product were obtained using a convergent strategy.
