105608-07-9Relevant academic research and scientific papers
IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS
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, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein NA (I) and pharmaceutically acceptable salts thereof.5 Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS
-
, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein formula (I) and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS
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, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having general formula (I), wherein R1 to R11 are as described herein, and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS
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, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein (I) and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
Separation material comprising phosphoryl choline derivatives
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, (2016/01/11)
The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material, which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also claimed is a device containing a column that comprises separation material made from formula (I) wherein L is a linker as defined in the claims; X is selected from: -SH, -NHR3, -C=CH, -CH=CH2, -N3, -CHO. Also claimed is a separation material of general formula (II): wherein A is a solid support; Y is a group obtainable from the reactive group X.
Efficient synthesis of amino-protected calix[4]arenes selectively functionalized with iron chelator ICL670 designed as platform for iron recognition
Rouge, Pascal,Becuwe, Mathieu,Dassonville-Klimpt, Alexandra,Nascimento, Sophie Da,Raimbert, Jean-Franois,Cailleu, Dominique,Baudrin, Emmanuel,Sonnet, Pascal
, p. 2916 - 2924 (2011/05/13)
The development of selective electrochemical iron sensor is still a challenging task. One promising possibility is to use organically functionalized inorganic particles, for instance silica, as sensitive element. Herein, we report on the design and synthesis of calix[4]arene-based platforms modified with ICL670 iron chelator and alkylamino chain(s). These new molecular edifices could be easily grafted on silica particles. The strategy relies on selective calix[4]arenes functionalizations by alkylamino chains at the lower rim, in partial-cone or 1,3-alternate conformations. The different synthesis routes are presented and discussed.
