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Galamustine, also known as BCNU, is a nitrosourea class of alkylating agent that serves as a chemotherapeutic drug. It is characterized by its ability to alkylate and crosslink DNA, thereby inhibiting the growth of cancer cells. Galamustine is notable for its capability to cross the blood-brain barrier, which makes it particularly effective in treating brain tumors.

105618-02-8

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105618-02-8 Usage

Uses

Used in Oncology:
Galamustine is used as a chemotherapeutic agent for the treatment of various types of cancer. Its primary application is in the treatment of brain tumors due to its ability to cross the blood-brain barrier. Additionally, it is utilized in the treatment of multiple myeloma and lymphoma.
The drug's mechanism of action involves the alkylation and crosslinking of DNA, which disrupts the replication and transcription processes in cancer cells, leading to their death. This makes galamustine a valuable tool in oncology for managing and combating cancerous growths.
However, the use of galamustine is accompanied by potential side effects such as bone marrow suppression, nausea, vomiting, and there are concerns regarding its long-term toxicity to organs like the lungs and kidneys. Despite these side effects, when administered properly and under medical supervision, galamustine remains an important and effective agent in the chemotherapy arsenal for cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 105618-02-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,6,1 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 105618-02:
(8*1)+(7*0)+(6*5)+(5*6)+(4*1)+(3*8)+(2*0)+(1*2)=98
98 % 10 = 8
So 105618-02-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H19Cl2NO5/c11-1-3-13(4-2-12)5-6-7(14)8(15)9(16)10(17)18-6/h6-10,14-17H,1-5H2/t6-,7+,8+,9-,10?/m1/s1

105618-02-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,4S,5R,6R)-6-[bis(2-chloroethyl)aminomethyl]oxane-2,3,4,5-tetrol

1.2 Other means of identification

Product number -
Other names Galamustina

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105618-02-8 SDS

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