10562-01-3

Upstream product

• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 62-53-3 aniline 

Downstream Products

• 118160-20-6 2,5-diphenyl-3-(phenylimino)-4-isoxazoline 
• 81016-22-0 β-Dianilino-α-benzoylthiocarbamoyl-α-benzoyl-ethylene 
• 81016-23-1 2-Phenyl-3-N-phenylamino-4-benzoyl-5-benzoylimino-Δ³-isothiazoline 
• 85590-27-8 (E)-2-(1-Benzoyl-2,2-bis-phenylamino-vinyl)-but-2-enedioic acid dimethyl ester 
• 78140-23-5 (5-Hydroxy-2-phenylamino-benzofuran-3-yl)-phenyl-methanone 
• 78140-16-6 (5-Hydroxy-1-phenyl-2-phenylamino-1H-indol-3-yl)-phenyl-methanone 
• 85590-36-9 6-Anilino-5-benzoyl-4-methoxycarbonyl-2-oxo-1-phenyl-1,2-dihydropyridine 
• 35746-43-1 3-phenyl-5-phenyloxazol-2(3H)-one 

Relevant academic research and scientific papers

PIDA-Mediated Formal Olefinic C=C Bond Cleavage of α-Oxo-Ketene N,N-Acetals toward Substituted Oxazolines

The hypervalent iodine reagent PhI(OAc)2 (PIDA) mediated the formal oxidative C=C bond cleavage and subsequent cyclization of internal olefins, that is, α-oxo-ketene N,N-acetals, which afforded substituted oxazolines. Isothiazoline derivatives were obtained from the reactions of α-thioxo-ketene N,N-acetals with PIDA under the same conditions. Hydrolysis of the resultant oxazoline derivatives led to highly functionalized oxazolones. A plausible mechanism was proposed based upon the formation of isothiazoline-type intermediates.

MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS

The present invention relates to monocyclic aroylpyridinones, processes for their preparation, and their use in medicaments, especially for the treatment of COPD: (formula I).