105655-17-2Relevant articles and documents
Synthesis of 3,5,7-substituted indoles via heck cyclisation
Charrier, Nicolas,Demont, Emmanuel,Dunsdon, Rachel,Maile, Graham,Naylor, Alan,O'Brien, Alistair,Redshaw, Sally,Theobald, Pam,Vesey, David,Walter, Daryl
, p. 3071 - 3074 (2005)
Traditional strategies in indole chemistry do not allow high yielding access to some substitution patterns such as 3,5,7-trisubstituted indoles. We report in this article the efficient synthesis of this type of indole. The Heck cyclisation strategy we use
STING PYRAZOLE AGONISTS AND USES THEREOF
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Paragraph 00353, (2020/07/14)
The present invention provides compounds, compositions thereof, and methods of using the same for the modulation of STING, and the treatment of STING-mediated disorders.
P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN
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Page/Page column 88, (2010/11/18)
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
Synthesis of indoles: Efficient functionalisation of the 7-position
Charrier, Nicolas,Demont, Emmanuel,Dunsdon, Rachel,Maile, Graham,Naylor, Alan,O'Brien, Alistair,Redshaw, Sally,Theobald, Pam,Vesey, David,Walter, Daryl
, p. 3467 - 3477 (2008/02/10)
Traditional strategies in indole chemistry do not allow high-yielding access to some substitution patterns such as 3,5,7-trisubstituted indoles. We report in this article the efficient synthesis of this type of indole. The Heck cyclisation strategy we use
TRICYCLIC INDOLE DERIVATIVES FOR USE IN THE TREATMENT OF ALZHEIMER’S DISEASE
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Page/Page column 19, (2010/11/08)
The present invention relates to novel ketone compounds of formula (I) having Asp2 (β-secretase, BACE1 or Memapsin-2) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases chara
TRICYCLIC INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER’S DISEASE
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Page 16, (2010/02/09)
The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β- amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.