1056683-09-0Relevant articles and documents
Novel 2,4-methanoadamantane-benzazepine by domino photochemistry of N-(1-adamantyl)phthalimide
Basaric, Nikola,Horvat, Margareta,Mlinaric-Majerski, Kata,Zimmermann, Elmar,Neudoerfl, Joerg,Griesbeck, Axel G.
, p. 3965 - 3968 (2008)
(Chemical Equation Presented) The photochemical reaction of N-(1-adamantyl)phthalimide (1) gives cleanly one product, the novel hexacyclic benzazepine derivative of 2,4-methanoadamantane 2. Its structure was characterized by spectroscopic methods and X-ray analysis and represent the first example of the 2-azahexacyclo[8.7.1.11,4.04,9.0 11,16.012,18]nonadeca-4,6,8-triene skeleton. The product is formed by a domino process of two consecutive excited-state intramolecular γ-hydrogen-transfer reactions. Base hydrolysis of the benzazepine 2 gives in high yield the keto derivative of the 1,2-substituted adamantane ε-amino acid 3.
Antiproliferative and antiviral activity of three libraries of adamantane derivatives
Basaric, Nikola,Sohora, Margareta,Cindro, Nikola,Mlinaric-Majerski, Kata,De Clercq, Erik,Balzarini, Jan
, p. 334 - 340 (2014/05/20)
Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.