1056757-68-6Relevant academic research and scientific papers
A convenient synthesis and biological activities of novel 6-aryl-3-(1,2,3,4-tetrahydroxybutan-1-yl)-7H-1,2,4-triazolo-[3,4-b][1,3,4] thiadiazines
Ye, Xiao-Xia,Zhang, Jin,Zhang, An-Jiang,Zhang, Li-Xue
, p. 987 - 991 (2008/09/21)
(Chemical Equation Presented) A series of novel 6-aryl-3-(1,2,3,4- tetrahydroxybutanol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines were easily synthesized in high yields by means of the reactions of 4-amino-5-(1,2,3,4-tetrahydroxybutyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (1) with substituted ω-bromoacetophenones or ω-chloroacetophenone. Nearly all of the title compounds possess plant growth-promoting activities.
New sulphonamide and carboxamide derivatives of acyclic C-nucleosides of triazolo-thiadiazole and the thiadiazine analogues. Synthesis, anti-HIV, and antitumor activities. Part 2
Al-Masoudi, Najim A.,Al-Soud, Yaseen A.
, p. 1034 - 1044 (2008/12/22)
A new series of acyclic C-nucleosides 1′,2′-O-isopropylidene-D- ribo-tetritol-1-yl)[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles bearing arylsulfonamide (5-8) and arylcarboxamide (9-12) residues have been synthesized under microwave irradiation. Thiadiazines 13-15 have been analogously prepared, and upon acid hydrolysis, afforded the free nucleosides 16-18. The new synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound 7 was also screened against a panel of tumor cell lines consisting of CD4 human T-cells. Copyright Taylor & Francis Group, LLC.
