1056884-99-1Relevant academic research and scientific papers
RCM-mediated stereoselective synthesis of three novel tetrahydroisoquinoline tetracyclic core frameworks
Huang, Qing-Qing,Chen, Lin-Hai,Nan, Fa-Jun
, p. 5141 - 5143 (2008/12/20)
Three novel tetrahydroisoquinoline tetracyclic core frameworks were stereoselectively synthesized. The key steps included a ring-closing metathesis (RCM)-mediated cyclization and a subsequent intramolecular SN2 N(O)-substituted reaction. This simple method for tetracyclic core synthesis facilitates the further exploration of the chemical space of tetrahydroisoquinoline alkaloids.
