105702-16-7

Upstream product

• 120-57-0 piperonal 
• 108-94-1 cyclohexanone 
• 10292-51-0 1-(trichloromethyl)-cyclopentanol 
• 670-80-4 4-cyclohexen-1-ylmorpholine 

Downstream Products

• 193208-99-0 2-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-cyclohexanone O-methyl-oxime 
• 1266550-46-2 (E)-N-(3-(2-(benzo[d][1,3]dioxol-5-ylmethylene)-1-hydroxycyclohexyl)prop-2-ynyl)-4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide 
• 69920-33-8 2-benzo[1,3]dioxol-5-ylmethylene-6-morpholin-4-ylmethyl-cyclohexanone 
• 105702-09-8 Benzo[1,3]dioxol-5-yl-(2-oxo-cyclohexyl)-acetonitrile 
• 105702-09-8 Benzo[1,3]dioxol-5-yl-(2-oxo-cyclohexyl)-acetonitrile 

Relevant academic research and scientific papers

Ring expansion/homologation-aldehyde condensation cascade using tert-trihalomethylcarbinols

Treatment of cyclic tert-trihalomethylcarbinols with CrCl2 in THF/HMPA in the presence of aryl or aliphatic aldehydes initiates a cascade sequence of one carbon ring expansion-olefination affording conjugated exocyclic ketones. Acyclic tert-trihalomethylcarbinols undergo a comparable cascade of one carbon homologation-olefination.

Modified calcium oxide as stable solid base catalyst for Aldol condensation reaction

A highly efficient and stable solid-base catalyst for Aldol condensation was prepared by modifying commercial CaO with benzyl bromide in a simple way. It was found that modified CaO can effectively catalyse the Aldol condensation of cyclohexanone and benzaldehyde, as well as various benzaldehydes, to produce 2-benzylidenecyclohexanone with a good selectivity and high yield. Higher yield of 95.8% was obtained over modified CaO after 3 h, which is short compared with the yield of 92.1% after 12 h over commercial CaO. The influence of several reaction parameters, such as temperature, catalyst loading, was investigated. The humidity test over modified CaO reveals that the basic centres of modified CaO are stable for CO2 and moisture. From the results of Fourier transform-infrared (FT-IR) and Thermogravity analysis (TG) characterization, the modifier was bonded on surface of CaO chemically and almost no Ca(OH) 2 formed during the modification process. The type of aldehyde has great influence on the yield of aldol condensation.

A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline-TEA through a new pathway

A novel and efficient direct aldol condensation from various ketones and a wide range of aldehydes was catalyzed by l-proline-TEA (triethylamine) in MeOH at room temperature, affording the corresponding (E)-α,β-unsaturated ketones in excellent yields. By

Synthesis of CIS- and trans- 2-arylmethylcycloalkylamines: Potential dopaminergic agents

This paper reports the synthesis and the study of a few new diastereomeric arylmethylcycloalkylamines, tested as potential dopamine receptor active agents. New procedures for the stereospecific synthesis of the arylmethylcycloalkylamines were successfully experimented. All the considered compounds did not show any appreciable dopamine receptor activity.

Synthesis of 2-amino-4-aryl-5,6,7,8-tetrahydro-4H-3,1-benzothiazines

The acid-catalyzed reaction of 2-arylidenecyclohexanones with thiourea afforded 4-aryl-2-imino-1,2,5,6,7,8-hexahydro-4H-3,1-benzothiazine hydrochlorides, which were converted into the corresponding bases.The structure of the 2-amino-4-aryl-5,6,7,8-tetrahy

APPROACHES TO THE TOTAL SYNTHESIS OF THE MONTANINE (AMARYLLIDACEAE) ALKALOIDS. PREPARATION OF ISOMERIC 3-ARYLOCTAHYDROINDOLES

The preparation of various isomeric 3-arylooctahydroindoles, potential synthons for the total synthesis of the montanine-like Amaryllidaceae alkaloids, is described.