105705-54-2

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 51106-84-4 3-(2,4-dimethoxyphenyl)-7-hydroxychroman-4-one 
• 108-46-3 recorcinol 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 1891-01-6 3-(2,4-dimethoxyphenyl)-7-hydroxy-4H-chromen-4-one 
• 115-18-4 2-methyl-3-buten-2-ol 
• 105705-51-9 2',4'-dimethoxy-7-(1,1-dimethylpropargyloxy)isoflavanone 
• 105705-47-3 5-deoxykievitone dimethyl ether 

Downstream Products

• 59870-70-1 (R)-3-(2,4-dimethoxyphenyl)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromene 
• 59870-68-7 glabridin 

Relevant academic research and scientific papers

Total synthesis of (±)-glabridin

An efficient formal synthesis of (±)-glabridin was accomplished in 10 steps from resorcinol using Raney Ni to reduce carbon-carbon double bonds in α,β-unsaturated carbonyl compound as the key step.

Synthesis of 5-Deoxykievitone Dimethyl Ether and Related Isopentenylated Isoflavanones

Three different 7-hydroxyisoflavanones (1a, 1b and 1c) have been converted into the corresponding 6'',6''-dimethylpyranoisoflavanones (4a, 4b and 4c) either through their 8-(3,3-dimethylallyl) derivatives (2a, 2b and 2c) or their 1,1-dimethylpropargyl ethers (3a, 3b and 3c).Among them, 2c is the dimethyl ether of naturally occurring 5-deoxykievitone.Attempts to synthesize the natural product itself by this route have been unsuccessful because demethylation of the starting desoxybenzoin (5) gives the corresponding 2-arylbenzofuran derivative (7a).