1057341-03-3

Basic information

• Product Name: O-tert-butyl N-[2-(iodomethyl)phenyl] carbamate
• Synonyms: O-tert-butyl N-[2-(iodomethyl)phenyl] carbamate
• CAS NO: 1057341-03-3
• Molecular Weight: 333.169
• Mol File: 1057341-03-3.mol

Chemical Properties

• CAS DataBase Reference: O-tert-butyl N-[2-(iodomethyl)phenyl] carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: O-tert-butyl N-[2-(iodomethyl)phenyl] carbamate(1057341-03-3)
• EPA Substance Registry System: O-tert-butyl N-[2-(iodomethyl)phenyl] carbamate(1057341-03-3)

Safety Data

• Hazardous Substances Data: 1057341-03-3(Hazardous Substances Data)

Upstream product

• 164226-32-8 2-(tert-butyloxycarbonyl)aminobenzyl alcohol 
• 5344-90-1 2-Aminobenzyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1186226-61-8 2-[(2-tert-butyloxycarbonylaminophenyl)methyl]thiosuccinic anhydride 
• 1006899-00-8 tert-Butyl {2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}carbamate 
• 1006898-92-5 4-[3-(2-aminobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile 
• 1178953-04-2 4-(4,4-dimethyl-2,5-dioxo-3-{2-[4-(2-oxopiperazin-1-ylmethyl)phenylamino]-benzyl}imidazolidin-1-yl)-2-trifluoromethylbenzonitrile 
• 1178953-41-7 benzyl 4-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)-3-oxopiperazine-1-carboxylate 
• 1179329-23-7 N-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}-C-(4-trifluoromethylphenyl)methanesulfonamide 
• 1179329-09-9 4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid 
• 1179329-74-8 4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonyl chloride 
• 1179329-08-8 4-(3-{2-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxo-imidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonamide 

Relevant articles and documents

Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof

The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof

The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

Thiomaleic anhydride: A convenient building block for the synthesis of α-substituted γ- and δ-lactones through free-radical addition, nucleophilic ring opening, and subsequent thiocarboxylate manipulation

(Chemical Equation Presented) Iodoalkyl tert-butyl carbonates and carbamates undergo clean free-radical addition to thiomaleic anhydride to give substituted thiosuccinic anhydrides in high yield on treatment with tris-(trimethylsilyl)silane and a radical initiator. After removal of the tert-butyloxycarbonyl group, cyclization then affords lactones or lactams substituted in the α-position by a thiocarboxylic acid residue. This group is converted to amides through reaction with electron-deficient sulfonamides or to aldehydes and/or ketones by the reaction of derived thioesters with either thiophenol, an electron-deficient allyl phenyl sulfide, or phenylboronic acid.