105740-29-2

Upstream product

• 2107-70-2 3,4-methoxycinnamic acid 
• 112276-28-5 (R)-3-cyano-3-(3,4-dimethoxyphenyl)-6-iodo-2-methylhexane 
• 112276-27-4 (S)-3-cyano-3-(3,4-dimethoxyphenyl)-6-iodo-2-methylhexane 
• 105740-28-1 3-cyano-3-(3,4-dimethoxyphenyl)-6-iodo-2-methylhexane 

Downstream Products

• 112276-29-6 2,7-Bis-(3,4-dimethoxy-phenyl)-6-isocyanato-2-isopropyl-heptanenitrile 
• 112276-29-6 (S)-2,7-Bis-(3,4-dimethoxy-phenyl)-6-isocyanato-2-isopropyl-heptanenitrile 
• 112276-29-6 (R)-2,7-Bis-(3,4-dimethoxy-phenyl)-6-isocyanato-2-isopropyl-heptanenitrile 
• 110469-83-5 (R)-2-(3,4-Dimethoxy-phenyl)-5-((R)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-isopropyl-pentanenitrile 
• 110469-83-5 (R)-2-(3,4-Dimethoxy-phenyl)-5-((S)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-isopropyl-pentanenitrile 
• 112276-31-0 (R)-5-((R)-6,7-Dimethoxy-3,4-dihydro-isoquinolin-3-yl)-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 112276-31-0 (R)-5-((S)-6,7-Dimethoxy-3,4-dihydro-isoquinolin-3-yl)-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 112276-38-7 (S)-3-<(R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhex-1-yl>-1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinoline 
• 112276-36-5 (R)-3-<(R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhex-1-yl>-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline 
• 105740-26-9 (3R,7R)-7-formamido-3,8-di-(3,4-dimethoxyphenyl)-2-methyl-3-octanenitrile 
• 112276-34-3 (3R,7S)-7-formamido-3,8-di-(3,4-dimethoxyphenyl)-2-methyl-3-octanenitrile 
• 110469-83-5 (S)-2-(3,4-Dimethoxy-phenyl)-5-((R)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-isopropyl-pentanenitrile 
• 112276-32-1 (S)-2-(3,4-Dimethoxy-phenyl)-5-((S)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-isopropyl-pentanenitrile 
• 112276-31-0 (S)-5-((R)-6,7-Dimethoxy-3,4-dihydro-isoquinolin-3-yl)-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 

Relevant academic research and scientific papers

SYNTHESIS AND DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY OF THE ENANTIOMERS OF 3-SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES RELATED TO THE CALCIUM ANTAGONIST VERAPAMIL

The four stereoisomers of 3--1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline (2) were prepared.The stereochemistry of the side chain quaternary carbon was derived from iodide 4 of known absolute conf

Tetrahydroisoquinoline derivatives

Compounds of the formula STR1 wherein R1 and R2 and each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or together form --OCH2 O-- or --OCH2 CH2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.