1057677-92-5

Basic information

• Product Name: 2-(6-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol
• Synonyms: 2-(6-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol
• CAS NO: 1057677-92-5
• Molecular Formula: C₂₇H₂₉N₅O
• Molecular Weight: 439.55206
• Mol File: 1057677-92-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(6-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol(1057677-92-5)
• EPA Substance Registry System: 2-(6-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol(1057677-92-5)

Safety Data

• Hazardous Substances Data: 1057677-92-5(Hazardous Substances Data)

Usage

Chemical structure

Contains piperazine, pyridine, and phthalazine moieties.

Derivative

It is a derivative of propan-2-ol.

Application

Used in medicinal chemistry as a potential drug candidate.

Pharmacological properties

Has various pharmacological properties.

Therapeutic applications

Studied for its potential use as a central nervous system depressant and in the treatment of neurological disorders.

Mechanism of action

The specific mechanism of action has yet to be fully elucidated.

Side effects

Potential side effects are not yet fully understood.

Biological activity

Its chemical structure suggests significant biological activity.

Pharmaceutical industry

It has potential for further development in the pharmaceutical industry.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 1057677-65-2 6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]nicotinic acid ethyl ester 

Downstream Products

• 1057678-76-8 N-(1-{6-[4-(4-benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyridin-3-yl}-1-methyl-ethyl)-acetamide 
• 1057678-74-6 1-benzyl-4-{4-[5-(1-methoxy-1-methyl-ethyl)-pyridin-2-yl]-piperazin-1-yl}-phthalazine 
• 1057682-26-4 1-benzyl-4-[4-(5-isopropenylpyridin-2-yl)piperazin-1-yl]phthalazine 
• 1449714-73-1 C₂₉H₂₉N₅O₂ 
• 1449714-70-8 C₂₇H₂₇N₅O₂ 
• 1449714-74-2 C₂₇H₂₅N₅O 
• 1449714-75-3 C₂₇H₂₇N₅O 

Relevant articles and documents

1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, that act via antagonism of the Smoothened receptor. A variety of analogues were synthesized and their structure-activity relationships determined. This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.