1057678-65-5 Usage
General Description
The chemical 1-(3-bromopropyl)-3-trifluoromethoxybenzene, also known as bromopropyl trifluoromethoxybenzene, is an organic compound with the molecular formula C10H10BrF3O. It is a colorless liquid at room temperature and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical is known for its strong reactivity and is often used in organic synthesis reactions, such as nucleophilic substitution and Grignard reactions. It is important to handle this compound with caution, as it may cause skin and eye irritation, and should be used in a well-ventilated area.
Check Digit Verification of cas no
The CAS Registry Mumber 1057678-65-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,7,6,7 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1057678-65:
(9*1)+(8*0)+(7*5)+(6*7)+(5*6)+(4*7)+(3*8)+(2*6)+(1*5)=185
185 % 10 = 5
So 1057678-65-5 is a valid CAS Registry Number.
1057678-65-5Relevant articles and documents
Boron tribromide as a reagent for anti-Markovnikov addition of HBr to cyclopropanes
Chen, Shuming,Gieuw, Matthew H.,Houk, K. N.,Ke, Zhihai,Yeung, Ying-Yeung
, p. 9426 - 9433 (2020)
Although radical formation from a trialkylborane is well documented, the analogous reaction mode is unknown for trihaloboranes. We have discovered the generation of bromine radicals from boron tribromide and simple proton sources, such as water ortert-butanol, under open-flask conditions. Cyclopropanes bearing a variety of substituents were hydro- and deuterio-brominated to furnish anti-Markovnikov products in a highly regioselective fashion. NMR mechanistic studies and DFT calculations point to a radical pathway instead of the conventional ionic mechanism expected for BBr3
