1057682-05-9

Basic information

• Product Name: (R)-6-(3-methylpiperazin-1-yl)nicotinonitrile
• Synonyms: (R)-6-(3-methylpiperazin-1-yl)nicotinonitrile
• CAS NO: 1057682-05-9
• Molecular Formula: C₁₁H₁₄N₄
• Molecular Weight: 202.25566
• Mol File: 1057682-05-9.mol

Chemical Properties

• Boiling Point: 400.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.54±0.40(Predicted)
• CAS DataBase Reference: (R)-6-(3-methylpiperazin-1-yl)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-(3-methylpiperazin-1-yl)nicotinonitrile(1057682-05-9)
• EPA Substance Registry System: (R)-6-(3-methylpiperazin-1-yl)nicotinonitrile(1057682-05-9)

Safety Data

• Hazardous Substances Data: 1057682-05-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-6-(3-methylpiperazin-1-yl)nicotinonitrile is used as a potential drug candidate for the development of medications targeting neurological disorders. Its activity in preclinical studies has shown promise for treating various conditions affecting the nervous system.
Used in Central Nervous System Stimulation:
As a central nervous system stimulant, (R)-6-(3-methylpiperazin-1-yl)nicotinonitrile is utilized for its potential to enhance cognitive function and alertness, which can be beneficial for conditions such as ADHD or fatigue.
Used in Treatment of Neurological Disorders:
(R)-6-(3-methylpiperazin-1-yl)nicotinonitrile is used as a therapeutic agent for the treatment of neurological disorders due to its demonstrated activity in preclinical studies, offering a new avenue for managing such conditions.
Used in Antipsychotic Medications:
(R)-6-(3-methylpiperazin-1-yl)nicotinonitrile is used as an antipsychotic agent, as it has been found to block certain receptors involved in dopamine signaling. This property makes it a promising candidate for the treatment of psychotic disorders, potentially offering new treatment options for patients suffering from such conditions.

Upstream product

• 33252-28-7 6-chloronicotinonitrile 
• 75336-86-6 (2R)-methylpiperazine 

Downstream Products

• 1057677-37-8 6-[(R)-4-(4-benzylphthalazin-1-yl)-3-methylpiperazin-1-yl]nicotinonitrile 

Relevant articles and documents

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, that act via antagonism of the Smoothened receptor. A variety of analogues were synthesized and their structure-activity relationships determined. This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.

ORGANIC COMPOUNDS AND THEIR USES

The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula (I).