1057746-53-8

Basic information

• Product Name: 2-{[(5-bromothiophen-2-yl) sulfonyl] amino}-4-chlorobenzoic acid
• CAS NO: 1057746-53-8
• Molecular Weight: 396.67
• Mol File: 1057746-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{[(5-bromothiophen-2-yl) sulfonyl] amino}-4-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(5-bromothiophen-2-yl) sulfonyl] amino}-4-chlorobenzoic acid(1057746-53-8)
• EPA Substance Registry System: 2-{[(5-bromothiophen-2-yl) sulfonyl] amino}-4-chlorobenzoic acid(1057746-53-8)

Safety Data

• Hazardous Substances Data: 1057746-53-8(Hazardous Substances Data)

Upstream product

• 55854-46-1 5-bromo-2-thiophenesulfonyl chloride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 

Relevant articles and documents

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors

A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a-c and 12a-c from a weak-binding fragment-like structure 1 as a starting point.