105784-82-5 Usage
Description
3'-azido-2',3'-dideoxy-5-bromouridine is a chemical compound that belongs to the class of nucleoside analogs. It is characterized by its unique structure, which features an azido group at the 3' position, a lack of a hydroxyl group at both the 2' and 3' positions, and a bromine atom at the 5' position of the uridine molecule. 3'-azido-2',3'-dideoxy-5-bromouridine has potential applications in various fields due to its distinct chemical properties and interactions with biological systems.
Uses
Used in Pharmaceutical Industry:
3'-azido-2',3'-dideoxy-5-bromouridine is used as a potential antitubercular agent for the development of new drugs against tuberculosis. It is particularly valuable in the biological study of virtual screening approaches, where it serves as a candidate compound for inhibiting thymidine monophosphate kinase, an essential enzyme in the bacterial growth and replication of Mycobacterium tuberculosis.
Used in Drug Design and Development:
In the field of drug design and development, 3'-azido-2',3'-dideoxy-5-bromouridine is utilized as a starting point for the creation of novel nucleoside analogs with improved antitubercular activity. Its unique structural features allow for the exploration of new chemical modifications and the optimization of its pharmacological properties, ultimately leading to the development of more effective and targeted treatments for tuberculosis.
Used in Research and Development of Diagnostic Tools:
3'-azido-2',3'-dideoxy-5-bromouridine may also find application in the research and development of diagnostic tools for tuberculosis. Its interaction with specific enzymes or cellular targets can be exploited to create assays or tests that detect the presence of the disease-causing bacteria, enabling faster and more accurate diagnosis of tuberculosis infections.
Check Digit Verification of cas no
The CAS Registry Mumber 105784-82-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,7,8 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 105784-82:
(8*1)+(7*0)+(6*5)+(5*7)+(4*8)+(3*4)+(2*8)+(1*2)=135
135 % 10 = 5
So 105784-82-5 is a valid CAS Registry Number.
105784-82-5Relevant articles and documents
Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs
Srivastav, Naveen C.,Shakya, Neeraj,Bhavanam, Sudha,Agrawal, Amogh,Tse, Chris,Desroches, Nancy,Kunimoto, Dennis Y.,Kumar, Rakesh
supporting information; experimental part, p. 1091 - 1094 (2012/03/26)
Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3′-azido-5-ethyl-2′,3′-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC 50 = 1 μg/mL), M. tuberculosis (MIC50 = 10 μg/mL) and M. avium (MIC50 = 10 μg/mL).
