1058227-35-2

Basic information

• Product Name: ethyl diethoxymethyl-(S_S,R_C,S_P)-(+)-(1-(tert-butylsulfinylamino)-(1-phenylethyl))phosphinate
• Synonyms: ethyl diethoxymethyl-(S_S,R_C,S_P)-(+)-(1-(tert-butylsulfinylamino)-(1-phenylethyl))phosphinate
• CAS NO: 1058227-35-2
• Molecular Weight: 419.522
• Mol File: 1058227-35-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl diethoxymethyl-(S_S,R_C,S_P)-(+)-(1-(tert-butylsulfinylamino)-(1-phenylethyl))phosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl diethoxymethyl-(S_S,R_C,S_P)-(+)-(1-(tert-butylsulfinylamino)-(1-phenylethyl))phosphinate(1058227-35-2)
• EPA Substance Registry System: ethyl diethoxymethyl-(S_S,R_C,S_P)-(+)-(1-(tert-butylsulfinylamino)-(1-phenylethyl))phosphinate(1058227-35-2)

Safety Data

• Hazardous Substances Data: 1058227-35-2(Hazardous Substances Data)

Upstream product

• 874291-45-9 (S)-2-methyl-N-(1-phenylethylidene)propane-2-sulfinamide 
• 65600-74-0 ethyl diethoxymethylphosphinate 

Downstream Products

• 1058227-57-8 (R)-1-amino-1-phenylethylphosphinic acid 

Relevant articles and documents

A concise and first synthesis of α-aminophosphinates with two stereogenic atoms leading to optically pure α-amino-H-phosphinic acids

A highly stereoselective synthesis of ω-aminophosphinates by nucleophilic attack of ethyl diethoxymethylphosphinate to Ellman's N-(tert-butanesulfinyl) ketimines by using Rb2CO3 as a base at room temperature was reported. In the first set of experiments, (S)-(tert-butane-sulfinyl)methyl (p-bromo)phenylketimine (1j) was used as the model compound to study its reaction with ethyl diethoxymethyl-phosphinate. Ethyl diethoxymethyiphosphinate and Rb2CO3 in CH 2Cl2 were placed in a 20 ml, Schienk flask and (5)-N-tert-butanesulfinylketimines 1 were then added at room temperature. The mixture was then stirred for 3-4 d, while being carefully monitored by TLC. The H NMR analysis showed that they have minor differences with shifts at 3.5 and 4.2 ppm, which can be assigned to the diethoxymethyl and the ethoxyl groups of the products.