105847-58-3Relevant academic research and scientific papers
Microbiological Transformations, Part 9. Microbiological Transformations of 1,2,5,6-Tetrahydropyrroloquinolin-4-one and of Derivatives of 1,2,3,5,6,7-Hexahydropyridoquinoline with the Fungus Cunninghamella elegans
Crabb, Trevor A.,Soilleux, Stephanie L.
, p. 5407 - 5414 (2007/10/02)
Incubation of 1,2,6,7-tetrahydropyridoquinolin-3(5H)-one with C. elegans resulted in oxidation at the C-7 benzylic position, whereas 1-methyl-1,2,6,7-tetrahydropyridoquinolin-5(3H)-one gave products resulting from oxidation at both benzylic positions. cis- and trans-1-Hydroxy-3-methyl-1,2,6,7-tetrahydropyridoquinolin-5(3H)-ones were produced on incubation of 5-methyl-1,2,6,7-tetrahydropyridoquinolin-3(5H)-one with C. elegans, in addition to trans-1-hydroxy-5-methyl-1,2,6,7-tetrahydropyridoquinolin-3(5H)-one.Incubation of 1,2,5,6-tetrahydropyrroloquinolin-4-one with C. elegans resulted in dehydrogenation to 1,2-dihydropyrroloquinolin-4-one.Incubation of 2,3,6,7-tetrahydropyridoquinolin-1(5H)-one with C. elegans resulted in benzylic attack at C-7.
