105859-08-3

Basic information

• Product Name: 2-(2,3,4,5-tetrafluoro-benzoyl)-3-(2,4-difluorophenyl)-ethyl acrylate
• Synonyms: 2-(2,3,4,5-tetrafluoro-benzoyl)-3-(2,4-difluorophenyl)-ethyl acrylate
• CAS NO: 105859-08-3
• Molecular Weight: 403.281
• Mol File: 105859-08-3.mol

Chemical Properties

• CAS DataBase Reference: 2-(2,3,4,5-tetrafluoro-benzoyl)-3-(2,4-difluorophenyl)-ethyl acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3,4,5-tetrafluoro-benzoyl)-3-(2,4-difluorophenyl)-ethyl acrylate(105859-08-3)
• EPA Substance Registry System: 2-(2,3,4,5-tetrafluoro-benzoyl)-3-(2,4-difluorophenyl)-ethyl acrylate(105859-08-3)

Safety Data

• Hazardous Substances Data: 105859-08-3(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 105859-06-1 (Z)-3-Ethoxy-3-(2,3,4,5-tetrafluoro-phenyl)-acrylic acid ethyl ester 
• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 105859-14-1 1-(2,4-difluorophenyl)-6,8-difluoro-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride 
• 105859-12-9 ethyl 1-(2,4-difluorophenyl)-6,8-difluoro-7-(3-acetamidopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 105859-18-5 1-(2,4-difluorophenyl)-6,8-difluoro-7-(4-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 105859-17-4 1-(2,4-difluorophenyl)-6,8-difluoro-7-piperazin-1-yl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 105859-15-2 6,7,8-Trifluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 105859-10-7 ethyl 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 

Relevant articles and documents

Carbostyril carboxylic compounds and intermediates, preparation method and application thereof

The invention discloses carbostyril carboxylic compounds and hydrochlorides thereof and also discloses a preparation method of the compounds and the hydrochlorides thereof as well as an application of the compounds and the hydrochlorides thereof in preparing gram-positive bacterium-preventing or gram-negative bacterium-preventing drugs. Moreover, the invention discloses intermediates for preparing the compounds and a preparation method of the intermediates.

Synthesis and Structure-Activity Relationship of 1-Aryl-6,8-difluoroquinolone Antibacterial Agents

A series of new arylfluoroquinolones has been prepared.These derivatives are characterized by having fluorine atoms at the 6- and 8-positions, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is 2,4-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(4-Fluorophenyl)-6,8-difluoro-7-piperazin-1-yl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (22) was found to possesss excellent in vitro potency and in vivo efficacy.