10586-40-0 Usage
Uses
Used in Pharmaceutical Industry:
(2Z)-4-acetyl-5-hydroxy-2-[(4-nitrophenyl)methylidene]thiophen-3(2H)-one is used as a synthetic intermediate for the development of pharmaceuticals. Its unique structure allows it to be a key component in the creation of various medicinal agents, potentially contributing to the treatment or management of different health conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (2Z)-4-acetyl-5-hydroxy-2-[(4-nitrophenyl)methylidene]thiophen-3(2H)-one is utilized as a building block for the assembly of more complex organic compounds. Its reactivity and functional groups make it suitable for further chemical reactions, leading to the formation of a wide range of specialized organic products.
Used in Chemical Research:
(2Z)-4-acetyl-5-hydroxy-2-[(4-nitrophenyl)methylidene]thiophen-3(2H)-one also serves as a valuable compound in chemical research. It can be employed to study reaction mechanisms, explore new synthetic routes, and investigate the properties of related compounds, thereby advancing the understanding of organic chemistry and its applications.
Check Digit Verification of cas no
The CAS Registry Mumber 10586-40-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,8 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10586-40:
(7*1)+(6*0)+(5*5)+(4*8)+(3*6)+(2*4)+(1*0)=90
90 % 10 = 0
So 10586-40-0 is a valid CAS Registry Number.
10586-40-0Relevant articles and documents
Design, Synthesis, and Antifungal Activities of 3-Acyl Thiotetronic Acid Derivatives: New Fatty Acid Synthase Inhibitors
Lv, Pei,Chen, Yiliang,Zhao, Zheng,Shi, Taozhong,Wu, Xiangwei,Xue, Jiaying,Li, Qing X.,Hua, Rimao
, p. 1023 - 1032 (2018/02/09)
Emerging fungal phytodiseases are increasingly becoming a food security threat. Twenty-six new 3-acylthiotetronic acid derivatives were designed, synthesized, characterized, and evaluated for activities against Valsa Mali, Curvularia lunata, Fusarium graminearum, and Fusarium oxysporum f. sp. lycopersici. Among the 26 compounds, 6f was the most effective against V. Mali, C. lunata, F. graminearum, and F. oxysporum f. sp. lycopersici with median effective concentrations (EC50) of 4.1, 3.1, 3.6, and 4.1 μg/mL, respectively, while the corresponding EC50 were 0.14, 6.7, 22.4, and 4.3 μg/mL of the fungicide azoxystrobin; 4.2, 41.7, 0.42, and 0.12 μg/mL of the fungicide carbendazim; and >50, 0.19, 0.43, and BS > 50 μg/mL of the fungicide fluopyram. The inhibitory potency against V. Mali fatty acid synthase agreed well with the in vitro antifungal activity. The molecular docking suggested that the 3-acylthiotetronic acid derivatives targeted the C171Q KasA complex. The findings help understanding the mode of action and design and synthesis of novel potent fungicides.
