1058676-79-1Relevant articles and documents
Poorly reactive 5-piperazin-1-yl-1,3,4-thiadiazol-2-amines rendered as valid substrates for Groebke-Blackburn type multi-component reaction with aldehydes and isocyanides using TMSCl as a promoter
Krasavin, Mikhail,Tsirulnikov, Sergey,Nikulnikov, Mikhail,Kysil, Volodymyr,Ivachtchenko, Alexandre
, p. 5241 - 5243 (2008/12/22)
N-Substituted 5-piperazin-1-yl-1,3,4-thiadiazol-2-amines that fail to undergo Groebke-Blackburn type MCR with aldehydes and isocyanides provide fair to good yields of the respective 2-piperazin-1-ylimidazo[2,1-b][1,3,4]thiadiazoles when such reaction is promoted by an equimolar quantity of trimethylsilyl chloride in aprotic medium. These findings further extend the utility of TMSCl as the isocyanide-based MCR promoter, and also demonstrate that this silicon Lewis acid is the actual promoter of the reaction.