1058744-63-0Relevant academic research and scientific papers
A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones
Ban, Shu-Rong,Zhu, Xi-Xia,Zhang, Zhi-Ping,Li, Qing-Shan
supporting information, p. 2517 - 2520 (2014/05/20)
A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions.
Asymmetric Michael addition of cyclohexanone or cyclopentanone to chalcones catalyzed by an L-proline-based organic phosphane
Liu, Lingyan,Zhu, Yunna,Huang, Kaimeng,Chang, Weixing,Li, Jing
, p. 2634 - 2645 (2013/06/04)
An organophosphane catalyst derived from L-proline was shown to be a very effective catalyst for asymmetric Michael addition reactions of various chalcones to cyclic ketones including both cyclohexanone and cyclopentanone. The corresponding adducts could
Direct asymmetric michael additions of ketones to nitroolefins and chalcones catalyzed by a Chiral C2-symmetric pyrrolidine-based tetraamine
Ma, Shijun,Wu, Lulu,Liu, Ming,Wang, Yongmei
, p. 2707 - 2713 (2013/01/15)
C2-Symmetric pyrrolidine-based tetraamine, available from commercially starting materials, showed good catalytic activity for asymmetric Michael additions of ketones to nitroalkenes especially to chalcones. The reactions proceeded to give the corresponding products in good yields and in a highly selective manner.
C2-symmetric proline-derived tetraamine as highly effective catalyst for direct asymmetric Michael addition of ketones to chalcones
Ma, Shijun,Wu, Lulu,Liu, Ming,Wang, Yongmei
experimental part, p. 3721 - 3729 (2012/05/20)
A C2-symmetric tetraamine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding adducts 1,5-dicarbonyl compounds were obtained in good chemical yields with high levels of diastereo- and enantioselectivities (up to >99:1 dr and 93% ee) under mild conditions. By studying the ESI-MS of the intermediates, a proposed mechanism was disclosed.
Highly enantioselective Michael addition of cyclic ketones to chalcones catalyzed by pyrrolidine-based imides
Xie, Hong-Yu,Ban, Shu-Rong,Liu, Ju-Na,Li, Qing-Shan
supporting information; experimental part, p. 3865 - 3868 (2012/08/14)
An efficient procedure for asymmetric Michael addition reaction of cyclic ketones with low activated chalcones catalyzed by pyrrolidine-based phthalimide and 1,8-Naphthalimide catalysts was developed. The corresponding products were obtained in high yield
