1058744-66-3Relevant academic research and scientific papers
Direct asymmetric michael additions of ketones to nitroolefins and chalcones catalyzed by a Chiral C2-symmetric pyrrolidine-based tetraamine
Ma, Shijun,Wu, Lulu,Liu, Ming,Wang, Yongmei
, p. 2707 - 2713 (2013/01/15)
C2-Symmetric pyrrolidine-based tetraamine, available from commercially starting materials, showed good catalytic activity for asymmetric Michael additions of ketones to nitroalkenes especially to chalcones. The reactions proceeded to give the corresponding products in good yields and in a highly selective manner.
C2-symmetric proline-derived tetraamine as highly effective catalyst for direct asymmetric Michael addition of ketones to chalcones
Ma, Shijun,Wu, Lulu,Liu, Ming,Wang, Yongmei
experimental part, p. 3721 - 3729 (2012/05/20)
A C2-symmetric tetraamine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding adducts 1,5-dicarbonyl compounds were obtained in good chemical yields with high levels of diastereo- and enantioselectivities (up to >99:1 dr and 93% ee) under mild conditions. By studying the ESI-MS of the intermediates, a proposed mechanism was disclosed.
Pyrrolidine-pyridine base catalysts for the enantioselective Michael addition of ketones to chalcones
Xu, Da-Zhen,Shi, Sen,Liu, Yingjun,Wang, Yongmei
experimental part, p. 9344 - 9349 (2010/01/06)
A series of pyrrolidine-pyridine base organocatalysts have been developed and 3a found to be a highly effective catalyst for the asymmetric Michael addition reactions of ketones to chalcones. The reaction generated the corresponding products 1, 5-diketone
