1059065-47-2

Upstream product

• 56967-27-2 5,7-dichloro-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 4743-17-3 5-Chloroisatoic anhydride 
• 14529-12-5 6-chloro-N-methylisatoic anhydride 
• 5973-28-4 7-chloro-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione 

Downstream Products

• 1059064-02-6 3-(2-bromobenzyl)-7-chloro-1-methyl-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one 

Relevant academic research and scientific papers

BENZODIAZEPINONE COMPOUNDS AND METHODS OF TREATMENT USING SAME

The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF

The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, vascular abnormalities, and the like.