1059067-91-2Relevant academic research and scientific papers
Total synthesis of the immunosuppressants myriocin and 2-epi-myriocin
Jones, Matthew C.,Marsden, Stephen P.
supporting information; experimental part, p. 4125 - 4128 (2009/05/27)
(Chemical Equation Presented) Total syntheses of the natural immunosuppressant myriocin (1) and the equipotent unnatural analogue 2-epi-myriocin (in protected form) have been achieved through a common strategy. The key transformations are the efficient synthesis of a quaternary (E)-vinylglycine by asymmetric deconjugative alkylation of a dehydroamino acid and an unusually highly diastereoselective dihydroxylation of the vinylglycine alkene.
