1059174-68-3Relevant academic research and scientific papers
BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY
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Page/Page column 106, (2017/07/14)
A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.
Discovery of selective and nonpeptidic cathepsin S inhibitors
Irie, Osamu,Ehara, Takeru,Iwasaki, Atsuko,Yokokawa, Fumiaki,Sakaki, Junichi,Hirao, Hajime,Kanazawa, Takanori,Teno, Naoki,Horiuchi, Miyuki,Umemura, Ichiro,Gunji, Hiroki,Masuya, Keiichi,Hitomi, Yuko,Iwasaki, Genji,Nonomura, Kazuhiko,Tanabe, Keiko,Fukaya, Hiroaki,Kosaka, Takatoshi,Snell, Christopher R.,Hallett, Allan
scheme or table, p. 3959 - 3962 (2009/04/06)
Nonpeptidic, selective, and potent cathepsin S inhibitors were derived from an in-house pyrrolopyrimidine cathepsin K inhibitor by modification of the P2 and P3 moieties. The pyrrolopyrimidine-based inhibitors show nanomolar inhibition of cathepsin S with
2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF
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Page/Page column 35, (2010/02/08)
The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.
