1059188-79-2Relevant academic research and scientific papers
1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS
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Page/Page column 32, (2009/12/05)
CB-1 receptor inverse agonist compounds of Formula and pharmaceutical compositions for the treatment of obesity or cognitive impairment associated with schizophrenia.
Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging
Donohue, Sean R.,Krushinski, Joseph H.,Pike, Victor W.,Chernet, Eyassu,Phebus, Lee,Chesterfield, Amy K.,Felder, Christian C.,Halldin, Christer,Schaus, John M.
experimental part, p. 5833 - 5842 (2009/09/25)
We have reported that [methyl-11C] (3R,5R)-5-(3-methoxyphenyl)- 3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)pyrrolidin-2-one ([ 11C]8, [11C]MePPEP) binds with high selectivity to cannabinoid type-1 (CB1/sub
