105919-40-2Relevant academic research and scientific papers
Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions
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, (2008/06/13)
Compounds of the general formula STR1 wherein: X is halogen or trifluoromethyl; R1 is hydrogen, halogen or trifluoromethyl; R2 is hydrogen, methyl or hydroxymethyl; R3 is hydrogen or lower alkyl; and Y is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia. The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
