105924-64-9

Basic information

• Product Name: 3,3,3-TRIFLUORO-1-(PHENYLSULFONYL)-1-PRO PENE
• Synonyms: 3,3,3-TRIFLUORO-1-(PHENYLSULFONYL)-1-PRO PENE;1-((E)-3,3,3-TRIFLUOROPROP-1-ENYLSULFONYL)BENZENE
• CAS NO: 105924-64-9
• Molecular Formula: C₉H₇F₃O₂S
• Molecular Weight: 236.2108896
• Mol File: 105924-64-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 68-71 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 3,3,3-TRIFLUORO-1-(PHENYLSULFONYL)-1-PRO PENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-TRIFLUORO-1-(PHENYLSULFONYL)-1-PRO PENE(105924-64-9)
• EPA Substance Registry System: 3,3,3-TRIFLUORO-1-(PHENYLSULFONYL)-1-PRO PENE(105924-64-9)

Safety Data

• Hazardous Substances Data: 105924-64-9(Hazardous Substances Data)

Usage

General Description

3,3,3-Trifluoro-1-(phenylsulfonyl)-1-propene is a chemical compound with the molecular formula C9H7F3O2S. It is a clear, colorless liquid with a strong, pungent odor. 3,3,3-TRIFLUORO-1-(PHENYLSULFONYL)-1-PRO PENE is mainly used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. It is also used as a solvent in various industrial applications. 3,3,3-Trifluoro-1-(phenylsulfonyl)-1-propene is known for its high reactivity and is flammable, so it must be handled and stored with care. Due to its chemical properties, it should be used under the guidance of trained professionals in a controlled environment.

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 110929-43-6 1,1,1-trifluoro-3-(phenylsulfonyl)propan-2-ol 

Downstream Products

• 533887-24-0 2-(phenylsulfonyl)-3-(trifluoromethyl)oxirane 

Relevant articles and documents

Beta-trifluoromethyl vinyl sulfone compounds as well as preparation method and application thereof

The invention belongs to the technical field of organic compounds and particularly provides beta-trifluoromethyl vinyl sulfone compounds, a preparation method thereof and an application of the compounds to tumor cell proliferation resistance. The beta-trifluoromethyl vinyl sulfone compounds are prepared from a multicomponent reagent (trifluoromethyl) trimethylsilane (TMSCF3), alkyne, diazonium salt and DABCO.(SO2)2 in an organic solvent DMSO through a one-step reaction. Reaction conditions are quite mild, alkyne bi-functionalization is realized directly through the one-step cascade reaction of the four raw materials, the operation is simple, defects of tedious steps, low operability and yield and poor selectivity of the traditional synthesis method of vinyl sulfone derivatives are overcome, and the method is applicable to large-scale preparation and has quite good application prospect. In-vitro pharmacological activity screening tests show that the compounds have an anti-proliferation effect on tumor cells, part of the compounds have an obvious tumor inhibition activity, the half maximal inhibitory concentration IC50 value can reach mu m level, and the compounds can be used for preparing a kind of novel anti-tumor reagents.

Regio- and stereo-selective synthesis of trifluoromethylated isoxazolidines by 1,3-dipolar cycloaddition of 1,1,1-trifluoro-3-phenylsulfonylpropene with nitrones, and their conversion into trifluoromethylated syn-3-amino alcohols

1,1,1-Trifluoro-3-phenylsulfonylpropene 1, a useful synthetic precursor for trifluoromethylated compounds, has been prepared from methyl phenyl sulfone 2 and ethyl trifluoroacetate.The 1,3-dipolar cycloaddition of 1 with various nitrones 5a-f gave 5-trifl