1059538-97-4Relevant academic research and scientific papers
Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)
Huynh, Tram,Chen, Zhong,Pang, Suhong,Geng, Jieping,Bandiera, Tiziano,Bindi, Simona,Vianello, Paola,Roletto, Fulvia,Thieffine, Sandrine,Galvani, Arturo,Vaccaro, Wayne,Poss, Michael A.,Trainor, George L.,Lorenzi, Matthew V.,Gottardis, Marco,Jayaraman, Lata,Purandare, Ashok V.
scheme or table, p. 2924 - 2927 (2010/03/03)
Design, synthesis, and SAR development led to the identification of the potent, novel, and selective pyrazole based inhibitor (7f) of Coactivator Associated Arginine Methyltransferase (CARM1).
Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)
Purandare, Ashok V.,Chen, Zhong,Huynh, Tram,Pang, Suhong,Geng, Jieping,Vaccaro, Wayne,Poss, Michael A.,Oconnell, Jonathan,Nowak, Kimberly,Jayaraman, Lata
supporting information; experimental part, p. 4438 - 4441 (2009/04/06)
This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.
