105955-01-9

Basic information

• Product Name: 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
• Synonyms: 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
• CAS NO: 105955-01-9
• Molecular Formula: C₁₇H₁₇NO₃
• Molecular Weight: 283.32178
• Mol File: 105955-01-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-(105955-01-9)
• EPA Substance Registry System: 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-(105955-01-9)

Safety Data

• Hazardous Substances Data: 105955-01-9(Hazardous Substances Data)

Upstream product

• 331-39-5 caffeic acid 
• 64-04-0 phenethylamine 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 13788-48-2 di-O-acetylcaffeic acid 
• 121-33-5 vanillin 
• 25528-22-7 3-Methoxy-4-methoxymethoxy cinnamic acid 
• 5533-00-6 3-methoxy-4-methoxymethoxy-benzaldehyde 
• 85708-49-2 N-phenethyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide 

Relevant articles and documents

Design, synthesis of N-phenethyl cinnamide derivatives and their biological activities for the treatment of Alzheimer's disease: Antioxidant, beta-amyloid disaggregating and rescue effects on memory loss

Gx-50 is a bioactive compound for the treatment of Alzheimer's disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1-20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, as well as comparison with literature data. Compounds 1-20 were evaluated for their anti-AD potential by using DPPH radical scavenging assay for considering their anti-oxidant activity, thioflavin T (ThT) fluorescence assay for considering the inhibitory or disaggregate potency of Ab, and transgenic Drosophila model assay for evaluating their rescue effect on memory loss. Finally, compound 13 was determined as a promising anti-AD candidate.

Protective effect of caffeic acid derivatives on tert-butyl hydroperoxide-induced oxidative hepato-toxicity and mitochondrial dysfunction in HepG2 cells

Oxidative stress results in structural and functional abnormalities in the liver and is thought to be a crucial factor in liver diseases. The aim of this study was to investigate the cytoprotective and antioxidant effects of caffeic acid (CA) derivatives

METHOD FOR ANTI-SKIN AGING USING CAFFEAMIDE DERIVATIVE

A method for anti-skin aging, especially for anti-skin photo-aging in a subject is provided. The method comprising administering to the subject an effective amount of an active component selected from the group consisting of a caffeamide derivative of for