1059552-26-9

Basic information

• Product Name: benzyl 4-{[(2-cyano-4,5-dimethoxyphenyl)amino]carbonyl}piperidine-1-carboxylate
• Synonyms: benzyl 4-{[(2-cyano-4,5-dimethoxyphenyl)amino]carbonyl}piperidine-1-carboxylate
• CAS NO: 1059552-26-9
• Molecular Weight: 423.469
• Mol File: 1059552-26-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 4-{[(2-cyano-4,5-dimethoxyphenyl)amino]carbonyl}piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-{[(2-cyano-4,5-dimethoxyphenyl)amino]carbonyl}piperidine-1-carboxylate(1059552-26-9)
• EPA Substance Registry System: benzyl 4-{[(2-cyano-4,5-dimethoxyphenyl)amino]carbonyl}piperidine-1-carboxylate(1059552-26-9)

Safety Data

• Hazardous Substances Data: 1059552-26-9(Hazardous Substances Data)

Upstream product

• 26961-27-3 2-amino-4,5-dimethoxybenzonitrile 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 

Downstream Products

• 1059552-27-0 benzyl 4-(6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)piperidine-1-carboxylate 

Relevant articles and documents

Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines

A new series of quinazolines that function as CCR4 antagonists were discovered during the screening of our corporate compound libraries. Subsequent compound optimization elucidated the structure-activity relationships and led the identification of 2-(1,4′-bipiperidine-1′-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine 14a, which showed potent inhibition in the [35S]GTPγS-binding assay (IC50 = 18 nM). This compound also inhibited the chemotaxis of human and mouse CCR4-expressing cells (IC50 = 140 nM, 39 nM).