105956-97-6Relevant articles and documents
Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
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, (2008/06/13)
The present invention provides a method of making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form, the method comprising dissolving a quinolone carboxylic acid salt or naphthyridine carboxylic acid salt in a solvent system to form a solution; combining the solution containing the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt with a calcium salt in an amount in the range of about 0.01% to about 5.0% by weight of the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt and a base, the combination resulting in the formation of a precipitate; and collecting the precipitate. Also provided is a solid bulk pharmaceutical chemical composition which is the product resulting from the precipitation.
Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
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, (2008/06/13)
An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a substituted amine to afford 3-amino-2,4,5-trifluorobenzoic acid followed by subsequent conversion of the amio intermediate into 3-chloro-2,4,5-trifluorobenzoic acid.
Process and intermediates for quinolonecaboxylic acid
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, (2008/06/13)
The present invention is concerned with a certain novel process for the preparation of a quinolonecarboxylic acid of the following formula; and with intermediates of the following formula; wherein R is hydrogen atom or lower alkyl group, X is halogen atom