105956-99-8 Usage
Chemical Properties
Pale Yellow Solid
Uses
Different sources of media describe the Uses of 105956-99-8 differently. You can refer to the following data:
1. antibacterial
2. A new fluoroquinolone antimicrobial agent as a potent intraphagocytic bactericidal agent for both gram-positive and gram-negative bacteria.
Biological Activity
clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both dna gyrase and topoisomerase iv dually in streptococcus pneumonia. clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.in selected volunteer subjects and patients, after the administration of oral and intravenous doses of racemic drug, the clinafloxacin showed a broad-spectrum antibiotic of the quinolone carboxylic acid category. the absorption of the clinafloxacin enantiomer was rapid after oral 400 mg dose and 400 mg intravenous dose of racemic drug [1]. clinafloxacin showed high activity against s. pneumoniae 7785 with the mic value of 0.125 μg/ml. clinafloxacin showed potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens [2]. clinafloxacin has been identified as the most active fluoroquinolone against s. pneumoniae compared to grepafloxacin, levofloxacin, ofloxacin, sparfloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].
references
[1]. humphrey g h, shapiro m a, randinitis e j, et al. pharmacokinetics of clinafloxacin enantiomers in humans[j]. the journal of clinical pharmacology, 1999, 39(11): 1143-1150.[2]. pan x s, fisher l m. dna gyrase and topoisomerase iv are dual targets of clinafloxacin action in streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 1998, 42(11): 2810-2816.[3]. jorgensen j h, weigel l m, swenson j m, et al. activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 2000, 44(11): 2962-2968.
Check Digit Verification of cas no
The CAS Registry Mumber 105956-99-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,9,5 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105956-99:
(8*1)+(7*0)+(6*5)+(5*9)+(4*5)+(3*6)+(2*9)+(1*9)=148
148 % 10 = 8
So 105956-99-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H17ClFN3O3.ClH/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9;/h5,7-9H,1-4,6,20H2,(H,24,25);1H
105956-99-8Relevant articles and documents
Preparation of 7-(3-amino- and 3-amino-methyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthyridonecarboxylic acids
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, (2008/06/13)
Process for the preparation of antibacterial compounds of the formula STR1 comprises condensing an oxo compound of the formula STR2 with an amino compound of the formula STR3 to produce a compound of the formula STR4 reacting the compound of the formula (III) with a compound of the formula STR5 to give a compound of the formula STR6 and then eliminating the amino-protective group STR7
