1059573-45-3

Usage

Molecular Weight

411.48 g/mol

Functional Groups

Bis(2-(2-methoxyphenoxy)ethyl)amino group
9H-carbazol-4-yloxy group
Propan-2-ol group

Structural Features

Contains two phenoxy rings connected to an ethyl group
Amino group connected to the bis(2-(2-methoxyphenoxy)ethyl) group
Carbazol-4-yloxy group attached to a propan-2-ol group

Potential Applications

Pharmaceutical industry (as a drug or chemical intermediate)

Properties

Complex organic compound
Synthetic chemical
May have properties useful for medicinal or chemical purposes

Further Research

Required to determine specific use and potential applications

Industry Relevance

Pharmaceutical and chemical industries

Upstream product

• 52602-39-8 9H-carbazol-4-ol 
• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 4463-59-6 2-(methoxyphenoxy)ethylbromide 
• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 
• 3258-70-6 2-(2-methoxyphenoxy)-N-[2-(2-methoxyphenoxy)ethyl]ethanamine 
• 90-05-1 2-methoxy-phenol 

Relevant academic research and scientific papers

Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug

Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright

Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel

Aminoglycosides (AGs) are broad-spectrum antibiotics used for the treatment of serious bacterial infections but have use-limiting side effects including irreversible hearing loss. Here, we assessed the otoprotective profile of carvedilol in mouse cochlear cultures and in vivo zebrafish assays and investigated its mechanism of protection which, we found, may be mediated by a block of the hair cell's mechanoelectrical transducer (MET) channel, the major entry route for the AGs. To understand the full otoprotective potential of carvedilol, a series of 18 analogues were prepared and evaluated for their effect against AG-induced damage as well as their affinity for the MET channel. One derivative was found to confer greater protection than carvedilol itself in cochlear cultures and also to bind more tightly to the MET channel. At higher concentrations, both carvedilol and this derivative were toxic in cochlear cultures but not in zebrafish, suggesting a good therapeutic window under in vivo conditions.