1059573-84-0Relevant academic research and scientific papers
Asymmetric synthesis of jaspine B (pachastrissamine) via an organocatalytic Aldol reaction as key step
Enders, Dieter,Terteryan, Violeta,Palecek, Jiri
, p. 2278 - 2282 (2008)
The asymmetric synthesis of jaspine B (pachastrissamine) using a (R)-proline-catalyzed enantioselective aldol reaction as key step is described. Jaspine B was synthesized from the commercially available and inexpensive 1-pentadecanal and the dihydroxyacetone equivalent 2,2-dimethyl-1,3-dioxan-5-one in nine steps, good overall yield (23.6%) and excellent stereoselectivity (de >98%, ee = 95%). Georg Thieme Verlag Stuttgart.
