1059592-16-3Relevant academic research and scientific papers
Synthesis of 3-(4-chlorophenyl)oxirane-2,2-dicarboxamide
Dotsenko,Krivokolysko,Rusanov,Gutov,Litvinov
, p. 1470 - 1473 (2007)
Oxidation of (E)-3-(4-chlorophenyl)-2-cyanoprop-2-enethioamide with hydrogen peroxide or the H2O2-KOH system gave 3-(4-chlorophenyl)oxirane-2,2-dicarboxamide. This compound was also obtained by an independent "one pot" synthesis from
Oxidation of 2-cyanoprop-2-enethioamides with hydrogen peroxide
Dotsenko,Krivokolysko,Shishkina,Shishkin
, p. 2082 - 2087 (2013/10/01)
Oxidation of (E)-3-aryl-2-cyanoprop-2-enethioamides with 32% H 2O2 under mild conditions gave (E)-3-aryl-2-cyano-1- iminioprop-2-ene-1-sulfenates in 70-88% yields. Under the conditions of the Radziszewski reaction (H2O2, 10% aqueous KOH) or upon prolonged treatment with H2O2, (E)-3-aryl-2-cyanoprop-2- enethioamides underwent transformations leading to complex mixtures of oxidation products. In some cases, 3-aryloxirane-2,2-dicarboxamides were isolated from those mixtures in low yields (2O2/KOH in ethanol afforded (arylaminomethylidene)malononitriles.
