10596-16-4

Usage

Uses

Used in Chemical Synthesis:
Tetraisopropyl 1,2-ethylenediphosphonate is used as a reactant in chemical synthesis processes for the production of various compounds. Its reactivity and stability make it a valuable component in the synthesis of complex molecules.
Used in Research Applications:
In the field of research, Tetraisopropyl 1,2-ethylenediphosphonate is used as a reagent to facilitate the study of chemical reactions and mechanisms. Its unique properties allow researchers to investigate the behavior of different molecules and their interactions.
Used in Pharmaceutical Industry:
Tetraisopropyl 1,2-ethylenediphosphonate is used as an intermediate in the synthesis of pharmaceutical compounds. Its role in the production of drugs is crucial, as it can contribute to the development of new medications and therapies.
Used in Material Science:
In material science, Tetraisopropyl 1,2-ethylenediphosphonate is used as a component in the development of new materials with specific properties. Its incorporation into materials can lead to the creation of advanced materials with applications in various industries.

InChI:InChI=1/C14H32O6P2/c1-11(2)17-21(15,18-12(3)4)9-10-22(16,19-13(5)6)20-14(7)8/h11-14H,9-10H2,1-8H3

Upstream product

• 1660-95-3 Tetraisopropyl methylenediphosphonate 
• 74-88-4 methyl iodide 
• 15267-38-6 thiophosphoric acid O,O'-diisopropyl ester S-phenyl ester 
• 917-54-4 methyllithium 
• 23331-94-4 NaCH(P(O)(O-i-Pr)2)2 
• 116-17-6 triisopropyl phosphite 
• 2574-25-6 Diisopropyl chlorophosphate 

Downstream Products

• 6145-33-1 ethylidene-1,1-bisphosphonic acid 

Relevant academic research and scientific papers

α-Azido bisphosphonates: Synthesis and nucleotide analogues

The first examples of α-azido bisphosphonates [(RO) 2P(O)]2CXN3 (1, R = i-Pr, X = Me; 2, R = i-Pr, X = H; 3, R = H, X = Me; 4, R = H, X = H) and corresponding β,γ- CXN3 dGTP (5-6) and α,β-CXN3 dATP (7-8) analogues are described. The individual diastereomers of 7 (7a/b) were obtained by HPLC separation of the dADP synthetic precursor (14a/b).

Phosphorothioate-mercaptophosphonate rearrangement: Synthesis of new o-mercaptoaryl-and omercaptoheteroaryl phosphonates and their derivatives

New o-mercaptoaryl and o-mcrcaptohetcroaryl phosphonates and their derivatives were prepared via an ori/io-lithiation of O,O-diisopropyl S-aryl, 5-(2-pyridyl), S-(2-thienyl) and 5-(3-thienyl) phosphorothioates followed by a phosphonyl group S → C migration. Elsevier,.

ZUR SYNTHESE UND REAKTIVITAET METHYLENVERBRUECKTER DIPHOSPHORYLVERBINDUNGEN

An improved high-yield Arbusov-type synthesis for diphosphorylmethanes with different substituents on both phosphorus atoms (4, 5, 7) by the reaction of isopropyl diphenylphosphinite or diisopropyl phenylphosphonite with diisopropyl bromomethylphosphonate (1) or isopropyl phenyl-bromomethylphosphinate (2), respectively, is described. 1 and 2 are available in yields of about 50 percent by the reaction of an excess of methylene bromide with triisopropylphosphite or diisopropyl phenylphosphonite, respectively.The metalation of the symmetrical and unsymmetrical diphosphorylmethanes 3-8 with NaH in toluene yields the corresponding carbanionic salts 3A-8A.Their structure and reactivity are investigated by means of 31P NMR spectroscopy and Horner-reactions with benzaldehyde.Regioselective monomethylation at the central carbon atom of 3-7 is performed using the phase-transfer technique.With exception of the phosphono-phosphinate derivative 14, on this way the appropriate 1,1-diphosphorylethanes 13 and 15-17 are obtained in high yield.Key words: diisopropyl bromomethylphosphonate; isopropyl phenyl-bromomethylphosphinate; diphosphorylmethanes; 31P-NMR; HORNER-reactions; 1,1-diphosphorylethanes