10596-26-6

Usage

Uses

Used in Water Treatment:
(dibromomethanediyl)bis(phosphonic acid) is used as a corrosion inhibitor for cooling water systems and oil fields. Its ability to form strong bonds with metal ions helps prevent corrosion and the formation of scale, thus enhancing the efficiency and longevity of these systems.
Used in Flame Retardants Production:
In the manufacturing industry, (dibromomethanediyl)bis(phosphonic acid) is utilized as a component in the production of flame retardants. Its chemical properties contribute to the effectiveness of these products in reducing the risk of fire and improving safety standards.
Used as a Stabilizer in Resins and Adhesives:
(dibromomethanediyl)bis(phosphonic acid) is also employed as a stabilizer for resins and adhesives, enhancing their durability and performance in various applications.
Used in Pharmaceutical Industry:
(dibromomethanediyl)bis(phosphonic acid) has applications in the pharmaceutical industry, where its unique properties can be harnessed for specific uses, although the exact applications are not detailed in the provided materials.
Used in Agricultural Industry:
Similarly, the compound finds use in the agricultural sector, although the specific applications are not specified in the materials provided.
Safety Precautions:
It is important to handle and store (dibromomethanediyl)bis(phosphonic acid) with care due to its toxic nature and potential to cause skin and eye irritation. Proper safety measures should be taken to minimize risks during its use and disposal.

Upstream product

• 10596-25-5 tetra-isopropyl dibromomethylene bisphosphonate 

Downstream Products

• 121151-61-9 dibromomethanediphosphonate tris(dicyclohexylammonium) salt 

Relevant academic research and scientific papers

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways

Bisphosphonates are a major class of drugs used to treat osteoporosis, Paget's disease, and cancer. They have been proposed to act by inhibiting one or more targets including protein prenylation, the epidermal growth factor receptor, or the adenine nucleotide translocase. Inhibition of the latter is due to formation in cells of analogs of ATP: the isopentenyl ester of ATP (ApppI) or an AppXp-type analog of ATP, such as AMP-clodronate (AppCCl2p). We screened both ApppI as well as AppCCl2p against a panel of 369 kinases finding potent inhibition of some tyrosine kinases by AppCCl2p, attributable to formation of a strong hydrogen bond between tyrosine and the terminal phosphonate. We then synthesized bisphosphonate preprodrugs that are converted in cells to other ATP-analogs, finding low nM kinase inhibitors that inhibited cell signaling pathways. These results help clarify our understanding of the mechanisms of action of bisphosphonates, potentially opening up new routes to the development of bone resorption, anticancer, and anti-inflammatory drug leads.

Transition state in DNA polymerase β Catalysis: Rate-Limiting chemistry altered by base-pair configuration

Kinetics studies of dNTP analogues having pyrophosphate-mimicking β,β-pCXYp leaving groups with variable X and Y substitution reveal striking differences in the chemical transition-state energy for DNA polymerase β that depend on all aspects of base-pairing configurations, including whether the incoming dNTP is a purine or pyrimidine and if base-pairings are right (T*A and G*C) or wrong (T*G and G*T). Br?nsted plots of the catalytic rate constant (log(kpol)) versus pKa4 for the leaving group exhibit linear free energy relationships (LFERs) with negative slopes ranging from -0.6 to -2.0, consistent with chemical rate-determining transition-states in which the active-site adjusts to charge-stabilization demand during chemistry depending on base-pair configuration. The Br?nsted slopes as well as the intercepts differ dramatically and provide the first direct evidence that dNTP base recognition by the enzyme-primer-template complex triggers a conformational change in the catalytic region of the active-site that significantly modifies the rate-determining chemical step.