1059704-55-0

Basic information

• Product Name: tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate
• Synonyms: tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate
• CAS NO: 1059704-55-0
• Molecular Weight: 385.242
• Mol File: 1059704-55-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate(1059704-55-0)
• EPA Substance Registry System: tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate(1059704-55-0)

Safety Data

• Hazardous Substances Data: 1059704-55-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate is a chemical compound with the molecular formula C12H21NO4I. It is a derivative of tert-butyl ester and is commonly used as a reagent in organic synthesis. The compound's structure contains a tert-butyl group, an amino group protected by a carboxybenzyl (Cbz) group, and an iodine atom attached to a four-carbon chain. Tert-butyl (3R)-3-(tert-butoxycarbonylamino)-4-iodobutanoate is utilized in various chemical reactions, including in the production of pharmaceutical compounds and as a building block in the synthesis of complex organic molecules.

Upstream product

• 155542-33-9 (R)-4-(tert-butoxy)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid 
• 439150-76-2 (R)-3-((tert-butoxycarbonyl)amino)-4-hydroxy-butyric acid tert-butyl ester 

Relevant articles and documents

BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS AND USES THEREOF

β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.