1059705-74-6

Basic information

• Product Name: tert-pentyl 2-chloro-4-(4-methylpiperazin-1-yl)benzoate
• Synonyms: tert-pentyl 2-chloro-4-(4-methylpiperazin-1-yl)benzoate
• CAS NO: 1059705-74-6
• Molecular Weight: 324.851
• Mol File: 1059705-74-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-pentyl 2-chloro-4-(4-methylpiperazin-1-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-pentyl 2-chloro-4-(4-methylpiperazin-1-yl)benzoate(1059705-74-6)
• EPA Substance Registry System: tert-pentyl 2-chloro-4-(4-methylpiperazin-1-yl)benzoate(1059705-74-6)

Safety Data

• Hazardous Substances Data: 1059705-74-6(Hazardous Substances Data)

Upstream product

• 185312-82-7 4-bromo-2-chlorobenzoic acid methyl ester 
• 109-01-3 1-methyl-piperazine 
• 14593-46-5 sodium tert-pentoxide 

Relevant articles and documents

Applicability aspects of transition metal-catalyzed aromatic amination protocols in medicinal chemistry

The application of palladium- and coppercatalyzed reactions for the aromatic amination of pharmacologically relevant scaffolds is investigated. The focus is set on the scope of several protocols for the introduction of amines of broad structural diversity, allowing for the synthesis of numerous derivatives of one biological hit structure for screening in biological assay systems. Thus, attaining optimized yields and TONs had not a major priority, most important were practical aspects, that is no further purification and drying of reagents and solvents had to be envisaged, ideally only a few transition metalbased protocols had to be applied for synthesizing structurally diverse compounds in sufficient amounts (several milligrams) for screening without any finetuning of conditions and catalytic systems.