105973-51-1Relevant articles and documents
Synthesis method of N-benzyl-3-hydroxypiperidine
-
Paragraph 0022; 0025-0026; 0029-0030; 0033, (2021/11/06)
The invention discloses a synthetic method of 3-hydroxypiperidine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking 3-hydroxypiperidine as a starting raw material, selectively protecting hydroxyl by using an optimized silicon protection reagent, then conducting reacting with benzyl halide under a weak alkaline condition, finally, conducting deprotecting under an acidic condition to obtain N-benzyl-3-hydroxypiperidine hydrochloride, and performing alkaline dissociation to obtain N-benzyl-3-hydroxypiperidine. The synthesis method has the advantages of cheap and easily available raw materials and reagents, mild reaction conditions, simple operation and high yield, and is suitable for industrial production.