105985-21-5 Usage
General Description
2-Chloro-5-(chloromethyl)pyrazine is a chemical compound with the molecular formula C6H5Cl2N3. It is a highly reactive and toxic compound that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its main applications include its use as a building block in the production of various drugs, fungicides, and pesticides. The compound is a clear, colorless to pale yellow liquid with a strong, pungent odor, and it is highly flammable. It is important to handle 2-Chloro-5-(chloromethyl)pyrazine with caution and use appropriate safety measures due to its hazardous nature.
Check Digit Verification of cas no
The CAS Registry Mumber 105985-21-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,9,8 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 105985-21:
(8*1)+(7*0)+(6*5)+(5*9)+(4*8)+(3*5)+(2*2)+(1*1)=135
135 % 10 = 5
So 105985-21-5 is a valid CAS Registry Number.
105985-21-5Relevant articles and documents
Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents
Long, Yi,Yu, Mingfeng,Li, Peng,Islam, Saiful,Goh, Aik Wye,Kumarasiri, Malika,Wang, Shudong
supporting information, p. 5674 - 5678 (2016/11/25)
Herein we disclose a series of novel heteroaryl styryl sulfone derivatives as potential anticancer agents. Structure-activity relationships of these newly synthesised compounds were explored with respect to the significance of the position and number of nitrogen atom of the heteroaryl ring for anti-proliferative activity in human cancer cell lines. A lead compound 14f was tested against a panel of cancerous and untransformed cell lines, and found to be highly potent against cancer cells with minimal toxicity in the untransformed cells. Further mechanistic studies uncovered that 14f caused cell-cycle arrest at the G2/M phase and induced apoptosis by targeting CDC25C and Mcl-1 proteins in A2780 ovarian cells.
