105986-52-5Relevant academic research and scientific papers
3-arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal
Battistuzzi, Gianfranco,Cacchi, Sandro,Fabrizi, Giancarlo,Bernini, Roberta
, p. 1133 - 1136 (2007/10/03)
The reaction of aryl halides with acrolein diethyl acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90°C affords ethyl 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. ortho-Substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields.
ARYLATION AND VINYLATION OF 2-CARBOETHOXYETHYLZINC IODIDE AND 3-CARBOETHOXYPROPYLZINC IODIDE CATALYZED BY PALLADIUM
Tamaru, Y.,Ochiai, H.,Nakamura, T.,Yoshida, Z.
, p. 955 - 958 (2007/10/02)
By the palladium catalysis 2-carboethoxyethylzinc iodide reacts with aryl iodides and vinyl iodides or triflates to provide the coupling products (ethyl 3-arylpropionates and ethyl 4-pentenoates, respectively) in satisfactory yields.The similar coupling reaction is observed for the reaction with 3-carboethoxypropylzinc iodide.
