105990-41-8

Basic information

• Product Name: 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R,3R,4S)-
• Synonyms: 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R,3R,4S)-;1,4-Dideoxy-1,4-iMino-D-ribitol
• CAS NO: 105990-41-8
• Molecular Formula: C₅H₁₁NO₃
• Molecular Weight: 133.15
• Mol File: 105990-41-8.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 319.1°Cat760mmHg
• Flash Point: 188.8°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 2.84E-05mmHg at 25°C
• Refractive Index: 1.554
• PKA: 14.13±0.60(Predicted)
• CAS DataBase Reference: 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R,3R,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R,3R,4S)-(105990-41-8)
• EPA Substance Registry System: 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R,3R,4S)-(105990-41-8)

Safety Data

• Hazardous Substances Data: 105990-41-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4+,5-/m1/s1

Upstream product

• 245484-08-6 (2S,3S,4S)-2-Hydroxymethyl-1-(4-methoxy-benzyl)-pyrrolidine-3,4-diol 
• 117858-84-1 N-benzyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol 
• 40773-81-7 ((2S,3S,4R)-2,3,4,5-Tetrahydroxy-pentyl)-carbamic acid benzyl ester 
• 136766-45-5 Trifluoro-methanesulfonic acid (3aR,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester 
• 136766-47-7 (3aR,4R,7R,7aR)-4-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ylamine 
• 160797-25-1 (2S,3R,4S)-N-(p-tolylsulfonyl)-3,4-dihydroxyproline-3,4-isopropylidene acetal methyl ester 
• 111193-62-5 (2S,3R,4S)-N-benzyloxycarbonyl-3,4-dihydroxyproline-3,4-isopropylidene acetal methyl ester 
• 111193-60-3 (S)-3,4-Dihydroxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 17645-35-1 (S)-3,4-Dihydroxy-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 186025-95-6 (Z)-3-((S)-2-Phenyl-4,5-dihydro-oxazol-4-yl)-acrylic acid methyl ester 
• 438552-26-2 (-)-(2R,3R,4S)-N-tert-butyloxycarbonyl-2-(2-furyl)-3,4-isopropylidenedioxypyrrolidine 
• 438552-25-1 (-)-(2R,3R,4S)-N-tert-butyloxycarbonyl-2-(2-furyl)pyrrolidine-3,4-diol 
• 438552-27-3 (-)-(2S,3R,4S)-N-tert-butyloxycarbonyl-2-carbomethoxy-3,4-isopropylidenedioxypyrrolidine 
• 438552-24-0 (-)-(4S)-N-tert-butyloxycarbonyl-N-(2-propenyl)-4-(2-furyl)-2(Z)-butenyl amine 

Downstream Products

• 100991-91-1 1,4-dideoxy-1,4-imino-L-arabinitol hydrochloride 
• 577978-62-2 3,5-di-O-benzyl-N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-2-O-methoxymethyl-D-ribitol 
• 872534-49-1 (2R,3R)-2,2,2-trichloroethyl-3-(benzyloxy)-2-(benzyloxymethyl)-4-oxopyrrolidine-1-carboxylate¹ 
• 577978-35-9 3,5-di-O-benzyl-1,4-dideoxy-1,4-imino-N-(2,2,2-trichloroethoxycarbonyl)-D-ribitol 
• 1360619-12-0 tert-butyl (3aR,4R,6S,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-6-(3-ethenylphenyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate 
• 1360619-13-1 tert-butyl (3aR,4R,6S,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-6-{3-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}-2,2-dimethyl-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate 
• 1360619-08-4 (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-{3-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]phenyl}prop-2-enamide hydrochloride 
• 1360619-11-9 (3aR,4R,6S,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)-6-(3-ethenylphenyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole 
• 153172-31-7 (3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole 
• 117894-12-9 (2S,3S,4S)-3,4-dihydroxy-2-hydroxymethyl-1-methylpyrrolidine 
• 1333523-99-1 (2S,3S,4S)-3,4-diacetoxy-2-[(2,3,5-tri-O-benzoyl-α-L-arabinofuranosyloxy)methyl]pyrrolidine 
• 1333523-84-4 (2S,3S,4S)-3,4-dihydroxy-1-(tert-butoxycarbonyl)-2-[(2,3,5-tri-O-benzoyl-α-L-arabinofuranosyloxy)methyl]pyrrolidine 
• 1333524-01-8 (2S,3S,4S)-3,4-diacetoxy-2-[(2,3,5-tri-O-benzoyl-α-L-arabinofuranosyl-(1->5)-2,3-di-O-benzoyl-α-L-arabinofuranosyloxy)methyl]pyrrolidine 
• 1333523-86-6 (2S,3S,4S)-3,4-dihydroxy-1-(tert-butoxycarbonyl)-2-([2,3,5-tri-O-benzoyl-α-L-arabinofuranosyl-(1->5)-2,3-di-O-benzoyl-α-L-arabinofuranosyloxy]methyl)pyrrolidine 

Relevant articles and documents

A New Strategy for the Diastereoselective Synthesis of Polyfunctionalized Pyrrolidines

This paper describes a new strategy for the synthesis of polyfuncticnalized pyrrolidines via the ring-closing metathesis reaction of substituted 3-allyl-4-vinyl-2-oxazolindones and subsequent diastereoselective cis-dihydroxylation of the resulting pyrrolo

METHODS OF TREATING POMPE DISEASE

Disclosed herein are novel uses of ADMDP stereoisomers or their derivatives for the manufacture of a medicament for treating Pompe disease. Accordingly, the present disclosure provides a method of treating Pompe disease in a subject. The method includes the step of, administering to the subject a therapeutically effective amount of a compound of formula (I), or a salt, an ester or a solvate thereof, wherein R1 and R2 are independently H or alkyl optionally substituted by -NH2 or -OH, so as to ameliorate, alleviate mitigate and/or prevent symptoms associated with the Pompe disease. According to certain embodiments of the present disclosure, the compound of formula (I) may serve a stabilizer of α-glucosidase via preventing its denaturalization of deactivation.

An efficient synthesis of 1,4-dideoxy-1,4-imino-d- and l-arabinitol and 1,4-dideoxy-1,4-imino-d- and l-xylitol from chiral aziridines

A highly efficient method for the synthesis of 1,4-dideoxy-1,4-imino-d- and l-arabinitol (d-AB1, 1 and l-AB1, 3) and 1,4-dideoxy-1,4-imino-d- and l-xylitol (d-DIX, 2 and l-DIX, 4) starting from commercially available chiral aziridines was developed. The g