106012-57-1Relevant articles and documents
C-3 Hydroxylation of Some Imidazoazines
Teulade, Jean C.,Bonnet, Pierre A.,Rieu, Jean N.,Viols, Henry,Chapat, Jean P.,et al.
, p. 1842 - 1874 (2007/10/02)
Reactions of imidazopyridine, pyrimidine and pyrazine (1)-(3) with formaldehyde or acetaldehyde give the corresponding alcohols and secondary products characterized by 1H and 13C n.m.r.X-Ray crystallographic analysis confirms the structure of (6).The two-step sequence of n-butyllithium and reaction with aldehydes with (2)-(3) does not lead to the alcohols but to n-butyl derivatives with substituents at C(7) and C(8) respectively.