106017-08-7

Basic information

• Product Name: Rufloxacin hydrochloride
• Synonyms: RUFLOXACIN HCL;RUFLOXACIN HYDROCHLORIDE;7h-pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylicacid,2,3-dihydro-9-fluoro-1;mf-934;RUFLOXACINHYDROCHLORIDE(SUBJECTTOPATENTFREE);2,3-Dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride;7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride(1:1)
• CAS NO: 106017-08-7
• Molecular Formula: C17H19ClFN3O3S
• Molecular Weight: 399.87
• Mol File: 106017-08-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 322-324℃
• Boiling Point: 574.6 °C at 760 mmHg
• Flash Point: 301.3 °C
• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Heated), Water (Very Slightly)
• CAS DataBase Reference: Rufloxacin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Rufloxacin hydrochloride(106017-08-7)
• EPA Substance Registry System: Rufloxacin hydrochloride(106017-08-7)

Safety Data

• Hazardous Substances Data: 106017-08-7(Hazardous Substances Data)

Usage

Description

Rufloxacin hydrochloride is another fluoroquinolone orally active antibacterial structurally and mechanistically related to temafloxacin and tosufloxacin. It is useful for the treatment of respiratory and urinary tract infections and also chronic bacterial prostatitis. Good tissue penetration with long acting activity has been reported.

Originator

Mediolanum (Italy)

Uses

Rufloxacin Hydrochloride inhibits human organic cation transporter 1 (hoCT1) (SLC22A1) but not hOCT2 (SLC22A2), and hOCT3 (SLC22A3) expressed in human embryonic kidney cell.

Brand name

Qari; Monos

InChI:InChI=1/C17H18FN3O3S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H

Upstream product

• 108860-30-6 ethyl 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl acetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 60-23-1 Cysteamine 
• 138944-12-4 ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-(1-mercaptoeth-2-ylamino)-acrylate 
• 113933-55-4 ethyl 2-<2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)-benzoyl>-3-dimethylaminoacrylate 
• 138944-13-5 ethyl 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylate 

Related news

Optimization and validation of a CZE method for Rufloxacin hydrochloride (cas 106017-08-7) determination in coated tablets07/20/2019

A simple and rapid capillary electrophoresis method with UV detection was developed and validated for the determination of rufloxacin hydrochloride in coated tablets. An experimental design strategy (Doehlert design and desirability function) allowed the analytical parameters to be simultaneousl...detailed

Relevant articles and documents

QUINOLINE DISULFIDES AS INTERMEDIATES

A process for preparing rufloxacin using a compound of the formula I (I) as a starting material is described, where R is herein defined.

Quinilone disulfide as intermediates

A process for preparing rufloxacin using a compound of the formula I STR1 as a starting material is described, where R is herein defined.

Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride

Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride (Rufloxacin) by reaction of 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)benzoyl ethyl acetate with N,N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanethiol, intramolecular cyclization by treatment with NaH, hydrolysis with H2 O and salification with HCl.